Jae-Seong Lee, MD
Board-certified Obstetrician and Gynecologist · Ultrasound-Guided HIFU (USgHIFU) since 2010
Director, AegisRoen Obstetrics & Gynecology Clinic, Seoul, Korea
Jae-Seong Lee, MD (이재성; also listed as Jae Seong Lee) is a Korean obstetrician and gynecologist who began ultrasound-guided high-intensity focused ultrasound (USgHIFU) treatment for uterine fibroids and adenomyosis on 1 February 2010 at Incheon Christian Hospital. He has personally performed more than 3,000 HIFU procedures (as of September 2024) and has published peer-reviewed research on the efficacy, safety, ovarian reserve, long-term outcomes and standardization of USgHIFU.
HIFU Clinical Experience
Career
- 2007–2015 — Head of Obstetrics & Gynecology and Director of the HIFU (Uterine Fibroid) Center, Incheon Christian Hospital
- 2009 — HIFU training at the Chongqing HIFU Center, China
- February 2010 — Began ultrasound-guided HIFU for uterine fibroids and adenomyosis
- 2012 — Invited lecture on USgHIFU at the 98th Annual Congress of the Korean Society of Obstetrics and Gynecology (KSOG)
- 2012 — Cooperating specialist in the New Health Technology Assessment application for USgHIFU
- 2013 — USgHIFU for uterine fibroids and adenomyosis listed as a new health technology (Ministry of Health and Welfare Notice No. 2013-102)
- 2015 — Clinical expert advisor to the Health Insurance Review and Assessment Service (HIRA)
- 2017 — Board member, International Society of Minimally Invasive Medicine (ISMINIM)
- Current — Director, AegisRoen Obstetrics & Gynecology Clinic (formerly Aegis Women's Clinic), Seoul
- Current — Adjunct Professor, Department of Obstetrics and Gynecology, Inha University College of Medicine
- Current — Adjunct Professor, Incheon St. Mary's Hospital, The Catholic University of Korea
- Current — Director, International HIFU Training Center
Memberships
- Korean Society of Obstetrics and Gynecology
- Korean Society of Gynecologic Endocrinology
- Korean Society of Gynecologic Endoscopy
HIFU procedures per year, 2010–2016
| Year | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 |
|---|---|---|---|---|---|---|---|
| Cases | 12 | 81 | 274 | 355 | 514 | 222 | 232 |
Research
16-year retrospective analysis of USgHIFU in Korea
A 16-year retrospective analysis of ultrasound-guided HIFU for uterine fibroids and adenomyosis in Korea, and the need for clinical standardization.
International Journal of Hyperthermia, 2026. doi:10.1080/02656736.2026.2700021
3D-grid navigation protocol for USgHIFU
Technical description and clinical implementation of a 3D-grid navigation protocol to standardize ultrasound-guided HIFU.
WFUMB Ultrasound Open, 2026. doi:10.1016/j.wfumbo.2026.100121
Clinical results of USgHIFU for fibroids and adenomyosis
Single-center experience from Korea (Ultrasonics Sonochemistry, 2015), effects on benign uterine tumors (Journal of Korean Medical Science, 2016) and safety and efficacy (Ultrasound in Medicine & Biology, 2019).
Ovarian function and pregnancy after USgHIFU
Anti-Müllerian hormone changes after treatment (BJOG, 2017), impact on ovarian reserve (International Journal of Hyperthermia, 2020) and term deliveries after USgHIFU (Clinical and Experimental Obstetrics & Gynecology, 2018).
Procedure technique and pain control
Effect of paracervical block before USgHIFU for uterine fibroids and adenomyosis (Clinical and Experimental Obstetrics & Gynecology, 2022).
Wider applications and complications
HIFU with hysteroscopic resection for retained placenta accreta (2016), abdominal wall endometriosis (2019) and tumor lysis syndrome after HIFU (2015).
Publications
Peer-reviewed publications listed on ORCID 0000-0002-3988-1496, newest first.
- Clinical transitions amid rapid expansion: a 16-year retrospective analysis of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids and adenomyosis in Korea and the necessity for clinical standardization
- Standardizing ultrasound-guided HIFU using a 3D-grid navigation protocol: technical description and clinical implementation
- Effect of paracervical block before ultrasound-guided high-intensity focused ultrasound treatment in uterine fibroids and adenomyosis
- The impact of ultrasound-guided high-intensity focused ultrasound for uterine fibroids on ovarian reserve
- Safety and efficacy of ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroids and adenomyosis
- Abdominal wall endometriosis treatment by ultrasound-guided high-intensity focused ultrasound ablation: a case report
- Unintended pregnancies with term delivery following ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroid and adenomyosis
- Changes in anti-Müllerian hormone levels as a biomarker for ovarian reserve after ultrasound-guided high-intensity focused ultrasound treatment of adenomyosis and uterine fibroid
- High-intensity focused ultrasound combined with hysteroscopic resection to treat retained placenta accreta
- Effects of high-intensity focused ultrasound treatment on benign uterine tumor
- High intensity focused ultrasound treatment-induced tumor lysis syndrome in uterine myoma patient
- Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: a single center experience from the Republic of Korea
Conference Presentations
- 2012–2021 — HIFU research presented at the Korean Society of Obstetrics and Gynecology Annual Congress (98th–107th), beginning with the 2012 invited lecture
- 2013–2015 — Yangtze International Minimally Invasive & Non-invasive Conferences, China
- 2014–2015 — Taiwan Association of Obstetrics and Gynecology, CFOG (Taiwan), ACTA (Japan); HIFU training for doctors at Chang Gung Memorial Hospital, Taiwan
- 2015 — FIGO World Congress of Gynecology and Obstetrics (Abstract No. 1117)
- 2015 — Asia & Oceania Congress of Obstetrics and Gynecology (AOCOG)
- 2017 — Selected as one of the 8 best HIFU presentations at the 25th AOCOG
- 2022 — APAGE–ISMIVS HIFU webinar series, invited speaker
- 2023 — ISMINIM International Non-invasive Conference, Chongqing, China
- 2025 — Focused Ultrasound Foundation (FUSF), invited presentation on uterine HIFU
2012 Invited Lecture,
98th KSOG Annual Congress
At the 98th Annual Congress of the Korean Society of Obstetrics and Gynecology (KSOG), Jae-Seong Lee gave the invited lecture “A new option for treating uterine fibroids and adenomyosis: ultrasound-guided high-intensity focused ultrasound ablation.”
5 October 2012
Speaker: Jae-Seong Lee, Incheon Christian Hospital
Official confirmation from KSOG
In an official letter dated 26 December 2016, the Korean Society of Obstetrics and Gynecology confirmed that Jae-Seong Lee presented this topic in the invited lecture at the 98th Annual Congress, and that it had not previously been presented at the Society.
2012 New Health Technology
Assessment Application
On 25 June 2012, Incheon Christian Hospital applied to the Korean authorities for a New Health Technology Assessment of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids and adenomyosis.
Jae-Seong Lee is named in the application as the cooperating specialist in obstetrics and gynecology. The procedure was listed as a new health technology in February 2013.
2012 Design Registration:
HIFU Patient Treatment Chart
Jae-Seong Lee designed a dedicated patient treatment chart to record each HIFU patient's condition before and after treatment, and registered the design with the Korean Intellectual Property Office.
Filed 2 November 2012 (No. 2012-0052447) · Registered 17 December 2012 (Registration No. 30-0674013)
Design owner and creator: Jae-Seong Lee
Dating from the same year as the KSOG invited lecture and the new health technology application, it shows that HIFU treatment progress has been recorded in a standardized format from the early days of his practice.
2010–2015 Clinical Career
at Incheon Christian Hospital
This career certificate was issued by Incheon Christian Hospital on 12 January 2017. It states that Jae-Seong Lee served as Head of Obstetrics & Gynecology and Director of the HIFU (Uterine Fibroid) Center from 5 February 2007 to 23 September 2015, and records:
1 February 2010 — began HIFU treatment for uterine fibroids and adenomyosis.
26 June 2012 — took part as cooperating specialist in the new health technology assessment application for HIFU.
21 February 2013 — HIFU for uterine fibroids and adenomyosis listed as a new health technology (Ministry of Health and Welfare Notice No. 2013-102).
2015 Clinical Expert Advisor
to HIRA
In an official letter dated 3 March 2015, the Health Insurance Review and Assessment Service (HIRA) of Korea invited Jae-Seong Lee to its expert advisory meeting on reimbursement criteria for ultrasound-guided HIFU for uterine fibroids and adenomyosis.
He is listed among the attendees as the procedural expert, together with members recommended by the Korean Society of Radiology and HIRA's own expert advisors, to discuss clinical indications and reimbursement criteria.
Meeting: 10 March 2015, HIRA Annex 1
Researcher Profiles
- ORCID: https://orcid.org/0000-0002-3988-1496
- Google Scholar: Jae Seong Lee
- Main PubMed paper: PMID 26072367
- Korean version of this page: 이재성 원장 HIFU 학술·임상 이력
- Clinic: AegisRoen Obstetrics & Gynecology Clinic – HIFU Center, 3F Hwanam Tower, 337 Teheran-ro, Gangnam-gu, Seoul · +82-2-542-0100
